Synthesis of monocarbonyl analogues of curcumin containing 1-(4-nitrophenyl)-1H-pyrazole and 1,3-diphenyl-1H-pyrazole heterocyclics

Summary: Synthesis of 24 assymetric Monocarbonyl Analogues of Curcumin (MACs) which containing 1-(4-nitrophenyl)-1H-pyrazole and 1,3-diphenyl-1H-pyrazole heterocyclics was executed in terms of evaluating their biological activities. This process integrates intermediates A (1H-pyrazole-4-carbaldehyde derivatives) and intermediates B (4-phenylbut-3-en-2-one derivatives) through aldolisation reaction in particular condition. These compounds were structurally identified by melting point, thin layer chromatography, IR, MS, 1H-NMR and 13C-NMR. Keywords: curcumin, MACs, 1H-pyrazole, aldol condensation. Preprint

Recommended citation: Thi Khanh Ngan Nguyen, Quoc Hoai Nam Đoan, Bao Ngoc Nguyen, Thanh An Pham, Tran Anh Thu Vu, Anh Tien Le, Ngoc Tuyen Truong. Synthesis of monocarbonyl analogues of curcumin containing 1-(4-nitrophenyl)-1H-pyrazole and 1,3-diphenyl-1H-pyrazole heterocyclics. Vietnamese Pharmacy Journal (Accepted)